In 2016, nearly 4 million animals were used in research in the UK. Not only is animal research considered unethical and inhumane but it is also ineffective. Currently, about 90% of drugs that pass animal tests fail in clinical trials, mainly due to unpredicted side-effects or because they are ineffective in humans. There is a huge incentive to develop alternatives to animal testing. In vitro models have the potential to provide an ethical solution with improved scientific accuracy which is preferable from both an animal welfare and scientific perspective.
Session Chair: Gerry Kenna
Drug Safety Consultant and Pharmaceutical Director (Safer Medicines Trust)
Gerry's role is to innovate and forge a route to improved safety of medicines, through human-relevant methods that are accepted and used by scientists in academia and industry, and by regulatory agencies. He provides expert advice on the design, generation and interpretation of drug safety studies to biotechs, SMEs, large and small pharma and pre-competitive consortia. This aids effective discovery and development of safer drugs, and development of new safety testing strategies. It utilizes the extensive preclinical and clinical expertise in drug safety sciences (especially drug induced liver injury) he acquired whilst working in the pharmaceutical and agrochemical industries and in academia. He has actively supported drug discovery projects in CNS, infection, oncology and metabolic diseases therapy areas.
Dr Nirmal Perera
Field Application Specialist
New advanced in-vitro models developed by ATCC for toxicology and translational cancer research
Dr Marieke Hoonakker
Development of the cAMP reporter assay to replace the in vivo safety test for acellular pertussis vaccines
Dr Martin Clift
Swansea University Medical School
Advanced in vitro testing strategies to understand the lung cell-(nano)particle interaction at the air-blood barrier
Development of a novel human 3D in vitro model for evaluating new anti-fibrotic drugs
To be confirmed
Dr David Chau
University of Hertfordshire
Pasta la vista: a vegetarian approach to cell culture
Dr Diane Lee
University of Surrey
The use of an immortalised bovine alveolar type II (BATII) cell line in the construction of a bilayer model of the alveolus
Interested in presenting?
What papers are we looking for?
We are looking for a wide variety of papers on this topic to provide an academic and industry perspective.
Suggested topics include:
- Human-relevant in vitro toxicity models
- In vitro/in vivo exposure scaling
- Data interpretation and integration
- Qualification of in vitro models for use in human risk assessment
Get in touch via the below form and we will get back to you as soon as possible.