Session Overview

In 2016, nearly 4 million animals were used in research in the UK. Not only is animal research considered unethical and inhumane but it is also ineffective. Currently, about 90% of drugs that pass animal tests fail in clinical trials, mainly due to unpredicted side-effects or because they are ineffective in humans. There is a huge incentive to develop alternatives to animal testing. In vitro models have the potential to provide an ethical solution with improved scientific accuracy which is preferable from both an animal welfare and scientific perspective.

Session Chair: Gerry Kenna

Drug Safety Consultant and Pharmaceutical Director (Safer Medicines Trust)

Gerry's role is to innovate and forge a route to improved safety of medicines, through human-relevant methods that are accepted and used by scientists in academia and industry, and by regulatory agencies. He provides expert advice on the design, generation and interpretation of drug safety studies to biotechs, SMEs, large and small pharma and pre-competitive consortia. This aids effective discovery and development of safer drugs, and development of new safety testing strategies. It utilizes the extensive preclinical and clinical expertise in drug safety sciences (especially drug induced liver injury) he acquired whilst working in the pharmaceutical and agrochemical industries and in academia. He has actively supported drug discovery projects in CNS, infection, oncology and metabolic diseases therapy areas.

 

 

 

 

What papers are we looking for?

We are looking for a wide variety of papers on this topic to provide an academic and industry perspective.

Suggested topics include:

  • Human-relevant in vitro toxicity models
  • In vitro/in vivo exposure scaling
  • Data interpretation and integration
  • Qualification of in vitro models for use in human risk assessment

 

 

 

Click here to submit a title and abstract 

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The Presenters

 

Caroline Taylor

KTP Research Assistant

Manchester Metropolitan University

Perfusion Bioreactors for a 3D Cardiovascular Toxicological Model

Jan van der Valk

Project Manager

3Rs-Centre Utrecht Life Sciences, Utrecht University

The use of foetal bovine serum and its replacement to advance the ethical and scientific quality of in vitro methods

Marieke Hoonakker

Researcher

Utrecht University

Development of the cAMP reporter assay to replace the in vivo safety test for acellular pertussis vaccines

Silvia Scaglione

Researcher

National Research Council, University of Genova

 A technological approach to recapitulate the breast cancer metastatic model in vitro

To be confirmed

To be confirmed

Posters

David Chau (University of Hertfordshire) - Pasta la vista: a vegetarian approach to cell culture

 

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