Session Overview

Last year’s topics included:

The effect of media perfusion on the infection and drug activity against Leishmania major

Drug resistance mechanisms in FGFR-driven cancers

Micro-engineering novel model of kidney-on-chip involving cell sheet technology

A novel tool to study the perivascular clearance of Amyloid-beta, significance for Alzheimer’s disease

Can we Tissue Engineer an In Vitro Model of Osteoporosis?

Session Chair: Doris Wilflingseder

Vice Director at Division of Hygiene and Medical Microbiology (Medical University of Innsbruck)

Together with my work group at the Division of Hygiene and Medical Microbiology, I study various aspects of opsonization (acute-chronic phase of infection). We study different antigen-presenting cells exposed to opsonized/non-opsonized viral or fungal pathogens and consequently the impact of the opsonization pattern on capacity cell functions. Some infectious agents, i.e. HIV, developed mechanisms to resist and even exploit the host immune response and become persistent. Additionally, fungal infections play a role as opportunistic pathogens that gained importance in the last few years due to their common occurrence in immunocompromised patients. Therefore, we are investigating host-pathogen interactions in more detail by integrating innate (complement) and adaptive (antibodies) humoral immune components in all our experimental set-ups.

 

 

 

Recent Publications

 

Chandorkar, P. et al. “Fast-Track Development of an in Vitro 3D Lung/immune Cell Model to Study Aspergillus Infections.” Scientific Reports 7 (2017): 11644. PMC. Web. 15 Nov. 2017.

Posch W, Heimdörfer D, Wilflingseder D, Lass-Flörl C.” Invasive candidiasis: future directions in non-culture based diagnosis.” Expert Rev Anti Infect Ther. 2017 Sep;15(9):829-838. doi: 10.1080/14787210.2017.1370373. Epub 2017 Sep 7.

Wilmes A, Rauch C, Carta G, Kern G, Meier F, Posch W, Wilflingseder D, Armstrong L, Lako M, Beilmann M, Gstraunthaler G, Jennings P. “Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.” Toxicol In Vitro. 2017 Aug 15. pii: S0887-2333(17)30209-6. doi: 10.1016/j.tiv.2017.07.023.

Jukic E, Blatzer M, Posch W, Steger M, Binder U, Lass-Flörl C, Wilflingseder D. „Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.” Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00670-17. doi: 10.1128/AAC.00670-17.

Posch W, Steger M, Wilflingseder D, Lass-Flörl C. “Promising immunotherapy against fungal diseases.” Expert Opin Biol Ther. 2017 Jul;17(7):861-870. doi: 10.1080/14712598.2017.1322576. Epub 2017 May 2.

What papers are we looking for?

We are looking for a wide variety of papers on this topic to provide an academic and industry perspective.

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The Presenters

 

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