Session Overview

Last year’s topics included:

The effect of media perfusion on the infection and drug activity against Leishmania major

Drug resistance mechanisms in FGFR-driven cancers

Micro-engineering novel model of kidney-on-chip involving cell sheet technology

A novel tool to study the perivascular clearance of Amyloid-beta, significance for Alzheimer’s disease

Can we Tissue Engineer an In Vitro Model of Osteoporosis?

Session Chair: Doris Wilflingseder

Vice Director at Division of Hygiene and Medical Microbiology (Medical University of Innsbruck)

Together with my work group at the Division of Hygiene and Medical Microbiology, I study various aspects of opsonization (acute-chronic phase of infection). We study different antigen-presenting cells exposed to opsonized/non-opsonized viral or fungal pathogens and consequently the impact of the opsonization pattern on capacity cell functions. Some infectious agents, i.e. HIV, developed mechanisms to resist and even exploit the host immune response and become persistent. Additionally, fungal infections play a role as opportunistic pathogens that gained importance in the last few years due to their common occurrence in immunocompromised patients. Therefore, we are investigating host-pathogen interactions in more detail by integrating innate (complement) and adaptive (antibodies) humoral immune components in all our experimental set-ups.

Recent Publications


Chandorkar, P. et al. “Fast-Track Development of an in Vitro 3D Lung/immune Cell Model to Study Aspergillus Infections.” Scientific Reports 7 (2017): 11644. PMC. Web. 15 Nov. 2017.

Posch W, Heimdörfer D, Wilflingseder D, Lass-Flörl C.” Invasive candidiasis: future directions in non-culture based diagnosis.” Expert Rev Anti Infect Ther. 2017 Sep;15(9):829-838. doi: 10.1080/14787210.2017.1370373. Epub 2017 Sep 7.

Wilmes A, Rauch C, Carta G, Kern G, Meier F, Posch W, Wilflingseder D, Armstrong L, Lako M, Beilmann M, Gstraunthaler G, Jennings P. “Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.” Toxicol In Vitro. 2017 Aug 15. pii: S0887-2333(17)30209-6. doi: 10.1016/j.tiv.2017.07.023.

Jukic E, Blatzer M, Posch W, Steger M, Binder U, Lass-Flörl C, Wilflingseder D. „Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.” Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00670-17. doi: 10.1128/AAC.00670-17.

Posch W, Steger M, Wilflingseder D, Lass-Flörl C. “Promising immunotherapy against fungal diseases.” Expert Opin Biol Ther. 2017 Jul;17(7):861-870. doi: 10.1080/14712598.2017.1322576. Epub 2017 May 2.

What papers are we looking for?

Despite decades of extensive research efforts focusing on animal disease models, their relevance regarding human pathogenesis, prevention and treatment is limited. Therefore, human-based in vitro disease models capable of reflecting human physiology in more detail are needed. Higher differentiation achieved by three-dimensional cell growth or perfusion, use of more relevant co-cultures and next-generation technologies will drive human disease modelling.

We are looking for a wide variety of papers on this topic to provide an academic and industry perspective.

Interested in presenting?

Get in touch via the below form and we will get back to you as soon as possible.

The Presenters


Roeland Hanemaaijer

Senior Scientist


Development of a diet-induced disease-mimicking in vitro model of non-alcoholic steatohepatitis (NASH/ fibrosis)

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