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Session Overview

Current in vitro barrier models exhibit limitations and therefore developing new models has important applications in the study of internal barriers and associated diseases. It is important that improved models are developed to provide greater insight into fundamental molecular mechanisms underlying host-microbe interactions. Developing novel gut models increases the physiological relevance of in vitro methods of studying digestive health.

Session Chair: Professor Julian Marchesi, PhD

Professor of Digestive Health (Imperial College London and Cardiff University)

Julian Marchesi graduated from Cardiff University with a PhD in biochemistry (1992) and became interested in the role bacteria play in ecosystem function. During his post-doctoral years he developed an interest in the contribution of uncultured microbes to the maintenance and function of ecosystems i.e. molecular microbial ecology. He subsequently secured a Wellcome Trust Fellowship which extended his molecular microbial ecology interest and investigated, with culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants in pristine environments. After a short time investigating the deep biosphere he obtained a Lectureship (2001) in the Department of Microbiology, University College Cork, Ireland where he transferred these “omic” skills into the human gut and started to investigate the human gut ecosystem in health and disease. After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system. In 2015 he was promoted to Professor at Cardiff and in 2016 to Professor at Imperial College London.

 

 

 

 

 

 

The Presenters

 

Lianne Stevens

Junior Scientist

TNO

InTESTine on-a-chip: Towards a more physiological and predictive human intestinal barrier model

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Stefan Vaessen

Scientist/Lecturer/Facility Manager

University of Applied Sciences Utrecht

Stem cell-derived organoids cultured two-dimensionally: The benefits of organoids with the dosing convenience of epithelial cell lines

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Elena Naumovska

Scientist

MIMETAS

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

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Marta Calatayud Arroyo

FWO Postdoctoral Fellow

Ghent University

Development of a host microbe interaction in vitro model of the small intestine 

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Emma Hernandez-Sanabria

Postdoctoral Fellow

Ghent University

Celecoxib supplementation impacts compositional and functional features of in vitro gut microbial ecosystem

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Loulou Peisl

PhD Student

University of Luxembourg

immunoHuMiX – an in vitro model to study microbiome-immune system interactions

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Dr Jan Markus

Senior Scientist and Production Manager

MatTek

Modelling of Live Bacteria or Ligand-Induced Acute and Chronic Inflammation in the Gut using In Vitro 3D-Primary Reconstructed Human Small Intestinal Tissues (EpiIntestinal)

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Dr Andrew Hollins

Research Associate

Cardiff University

Current and future applications for intestinal organoid culture models

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Dr Mike Bracher

Senior Research Associate

University of Portsmouth

A Systematic Approach To Review of In vitro models in Brain Tumour Research (SAToRI-BTR)

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Posters

Annelore Beterams

Student

Ghent University

In vitro wound healing model of the gut

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Kyle Murphy

PhD Student

Cardiff University

The impact of dynamic flow and probiotics on intestinal cell lines

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Maria Howland

PhD Student

Cardiff University

Investigating the impact of flow on tight junctions in a novel model of the gut barrier

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Emma Hernandez-Sanabria

Postdoctoral Fellow

Ghent University

Celecoxib supplementation impacts compositional and functional features of in vitro gut microbial ecosystem

View Abstract

Lianne Stevens

Junior Scientist

TNO

InTESTine on-a-chip: Towards a more physiological and predictive human intestinal barrier model

View Abstract

Dr Jan Markus

Senior Scientist and Production Manager

MatTek

EpiIntestinal on a Chip: Label-free Microphysiometry

View Abstract

Interested in presenting?

What papers are we looking for?

We are looking for a wide variety of papers on this topic to provide an academic and industry perspective.

We are looking for papers which explore how we can better model the gut cells and its associated microbiota.  We need to try and understand how we can integrate the two major aspects of the gut to create better models to predict response and diseases.

 

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