Current in vitro barrier models exhibit limitations and therefore developing new models has important applications in the study of internal barriers and associated diseases. It is important that improved models are developed to provide greater insight into fundamental molecular mechanisms underlying host-microbe interactions. Developing novel gut models increases the physiological relevance of in vitro methods of studying digestive health.
Session Chair: Professor Julian Marchesi, PhD
Professor of Digestive Health (Imperial College London and Cardiff University)
Julian Marchesi graduated from Cardiff University with a PhD in biochemistry (1992) and became interested in the role bacteria play in ecosystem function. During his post-doctoral years he developed an interest in the contribution of uncultured microbes to the maintenance and function of ecosystems i.e. molecular microbial ecology. He subsequently secured a Wellcome Trust Fellowship which extended his molecular microbial ecology interest and investigated, with culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants in pristine environments. After a short time investigating the deep biosphere he obtained a Lectureship (2001) in the Department of Microbiology, University College Cork, Ireland where he transferred these “omic” skills into the human gut and started to investigate the human gut ecosystem in health and disease. After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system. In 2015 he was promoted to Professor at Cardiff and in 2016 to Professor at Imperial College London.
Alexander JL, Wilson ID, Teare J, Marchesi JR, Nicholson JK, Kinross JM, 2017, Gut microbiota modulation of chemotherapy efficacy and toxicity, Nature Reviews Gastroenterology & Hepatology, Vol:14, ISSN:1759-5045, Pages:356-365
Drake MJ, Morris N, Apostolidis A, Rahnama'i MS, Marchesi JR, 2017, The urinary microbiome and its contribution to lower urinary tract symptoms; ICI-RS 2015., Neurourol Urodyn, Vol:36, Pages:850-853
Kindinger LM, Bennett PR, Lee YS, Marchesi JR, Smith A, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, Maclntyre DA, 2017, The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk, Microbiome, Vol:5, ISSN:2049-2618
Kinross J, Mirnezami R, Alexander J, Brown R, Scott A, Galea D, Veselkov K, Goldin R, Darzi A, Nicholson J, Marchesi JR, 2017, A prospective analysis of mucosal microbiome-metabonome interactions in colorectal cancer using a combined MAS 1HNMR and metataxonomic strategy, Scientific Reports, Vol:7, ISSN:2045-2322
Lynch A, Crowley E, Casey E, Cano R, Shanahan R, McGlacken G, Marchesi JR, Clarke DJ, 2017, The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity., Sci Rep, Vol:7
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