Session sponsored by SpheriTech

Session Overview

Increasing the physiological relevance of cell cultures provides a better understanding of the in vivo situation. Three-dimensional (3D) cell culture systems and spheroids have gained increasing interest in drug discovery as they have the ability to provide more human relevant insights compared to traditional two-dimensional (2D) monolayer cultures. Culturing cells under flow allows transport of oxygen and nutrients and removal of waste products. Dynamic conditions more accurately mimic the environment within the body and therefore provide more predictive data than static conditions. Co-culture enables improved understanding of interactions between cell populations.

Session Chair: Professor Trevor Dale

Director of Technology (Cardiff University)

Trevor did his undergraduate in Biochemistry at Imperial College and then completed a PhD on interferon signal transduction at the Imperial Cancer Research Fund in 1989 (now Cancer Research UK, London Research Centre). During this time he became interested in the role of signalling pathways in development. Following a postdoctoral fellowship at Baylor College of Medicine in Houston, he established a research group at the Institute of Cancer Research in London in 1991. His group moved to Cardiff in November 2003.

The primary focus of research in the group is the regulation of the Wnt signal transduction pathway. Wnts together with other peptide ligands including the FGF, EGF, TGF-β and hedgehog families orchestrate cell-cell interactions throughout development. Much of the specificity of each ligand's function is controlled by intracellular pathways that are activated at the cell surface. Components of the Wnt/β-catenin pathway are frequently mutated in human cancer. The laboratory studies normal and oncogenic Wnt signalling using approaches ranging from biochemistry/structural biology, through cell and organoid based assays to murine models.

 

 

 

 

 

Session Chair: Doris Wilflingseder

Vice Director at Division of Hygiene and Medical Microbiology (Medical University of Innsbruck)

Together with my work group at the Division of Hygiene and Medical Microbiology, I study various aspects of opsonization (acute-chronic phase of infection). We study different antigen-presenting cells exposed to opsonized/non-opsonized viral or fungal pathogens and consequently the impact of the opsonization pattern on capacity cell functions. Some infectious agents, i.e. HIV, developed mechanisms to resist and even exploit the host immune response and become persistent. Additionally, fungal infections play a role as opportunistic pathogens that gained importance in the last few years due to their common occurrence in immunocompromised patients. Therefore, we are investigating host-pathogen interactions in more detail by integrating innate (complement) and adaptive (antibodies) humoral immune components in all our experimental set-ups.

The Presenters

 

Andrew Mearns Spragg

CEO

Jellagen

Next generation jellyfish collagen an opportunity for efficient 2D and 3D cell culture applications

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Dr Dania Movia

Senior Research Fellow

Trinity College Dublin

3D in vitro models of lung cancer: Understanding the model's characteristics to improve drugs translation

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Dr Dominik Egger

Research Associate

University of Natural Resources and Life Sciences (Vienna)

Dynamic three-dimensional aggregate cultivation for the expansion of mesenchymal stem cells

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Dr Lynne Bingle

Reader in Oral Science

University of Sheffield

The development of an organoid model of human salivary glands

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Dr Deborah Mason

Reader

Cardiff University

3D mechanically-loaded bone cell models for drug screening

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Professor Elisa Budyn

Professor

University of Paris-Saclay

Morphological and physiological changes of osteocytes during bone formatting in a bone-on-chip

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Sandro Meucci

R&D Scientist

Micronit Microtechnologies

Tailoring the extracellular environment of in vitro systems

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Nikolett Nagy

Field Application Scientist

Upcyte Technologies

Liver bud formation using differentiated human upcyte cells

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Nilofar Faruqui

Researcher 

National Physical Laboratory

Self-assembled Instructive Extracellular Mimics

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Dr Tamara Zietek

Research Group Leader

Technical University of Munich (Germany)

3D intestinal organoids: Functional studies on nutrient uptake, drug bioavailability and gut hormone secretion

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Roeland Hanemaaijer

Senior Scientist

TNO

Development of a diet-induced disease-mimicking in vitro model of non-alcoholic steatohepatitis (NASH/ fibrosis)

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Don Wellings

Managing Director

Spheritech Ltd

Proliferate - applications in regenerative medicine

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Arinzechukwu Ude

PhD Research Student

University of the West of England

Chemotherapy-induced bystander effect

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Marta Cavo

Post-doc

National Research Council, University of Genova

A technological approach to recapitulate the breast cancer metastatic model in vitro

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Dr Gary Allenby

Business Development Director and Chief Scientific Officer

Aurelia Bioscience

Application of novel 3-dimensional electrospun micro-scaffold technology as a drug discovery platform for cell biology

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TBC

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Posters

Kate Harper

Account Manager

PerkinElmer

Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix High Content Screening System

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Dr Gabrielle Wheway

Lecturer

University of the West of England

Contactless Electrical Impedance Spectroscopy (EIS) platform to monitor changes in cell morphology

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Nuria Abajo Lima

Researcher

Cardiff University

Scale up of organoid expansion and fractionation for their widespread use in preclinical drug discovery

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Jessica Pinheiro de Lucena-Thomas

Postgraduate Researcher

University of Bath

Microgel Matrices for Human Cancer Organoid Production

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Stefania Vernazza

Researcher

Cardiff University

Scale up of organoid expansion and fractionation for their widespread use in preclinical drug discovery

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Anna Maria Bassi

Researcher

University of Genova

A new hydrogel sponge scaffold suitable for 3D cell culture

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Zahra Khodabandeh

Researcher

Shiraz University

Fabrication of enriched scaffold by extracellular matrix of mesenchymal stem cells in 3D culture

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Dr Malin Darnell

DMPK Associate Principal Scientist

AstraZeneca

Liver-Chip and Liver Spheroids as Models to Determine Hepatic Safety and Metabolism

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Charlotte De Rudder

PhD Student

Ghent University

Host-microbe interaction in the upper respiratory tract: development of a polymicrobial model of the sinonasal microenvironment

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Dr Sharon Dewitt

Lecturer

Cardiff University

Engineering a 3D cartilage model from human stem cells

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TBC

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